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Article

An evolutionary path to altered cofactor specificity in a metalloenzyme.

Nature communications - 1 Jun 2020

Barwinska-Sendra Anna, Garcia Yuritzi M, Sendra Kacper M, Baslé Arnaud, Mackenzie Eilidh S, Tarrant Emma, Card Patrick, Tabares Leandro C, Bicep Cédric, Un Sun, Kehl-Fie Thomas E, Waldron Kevin J

Abstract excerpt

Almost half of all enzymes utilize a metal cofactor. However, the features that dictate the metal utilized by metalloenzymes are poorly understood, limiting our ability to manipulate these enzymes for industrial and health-associated applications. The ubiquitous iron/manganese superoxide dismutase (SOD) family exemplifies this deficit, as the specific metal used by any family member cannot be predicted....

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Identifiers

PMID: 32483131
DOI: 10.1038/s41467-020-16478-0
PMCID: PMC7264356

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