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Article

Heterogeneity in the Histidine-brace Copper Coordination Sphere in Auxiliary Activity Family 10 (AA10) Lytic Polysaccharide Monooxygenases.

The Journal of biological chemistry - 10 Jun 2016

Chaplin Amanda K, Wilson Michael T, Hough Michael A, Svistunenko Dimitri A, Hemsworth Glyn R, Walton Paul H, Vijgenboom Erik, Worrall Jonathan A R

Abstract excerpt

Copper-dependent lytic polysaccharide monooxygenases (LPMOs) are enzymes that oxidatively deconstruct polysaccharides. The active site copper in LPMOs is coordinated by a histidine-brace. This utilizes the amino group and side chain of the N-terminal His residue with the side chain of a second His residue to create a T-shaped arrangement of nitrogen ligands. We report a structural, kinetic, and thermodynamic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27129229
DOI: 10.1074/jbc.M116.722447
PMCID: PMC4933455

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