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Prognostic impact of TP53 mutations in adult acute lymphoblastic leukemia treated with a pediatric-type regimen.

Leukemia & lymphoma - 1 Feb 2024

Ou Jiawang, Xu Xiuli, Deng Shiyu, Liang Haimei, Cai Zihong, Li Jia, Huang Zicong, Tang Bingqing, Wang Zhixiang, Zhou Ya, Liu Xiaoli, Liu Qifa, Zhou Hongsheng

Abstract excerpt

The prognostic impact of TP53 mutations (TP53mut) in adult acute lymphoblastic leukemia (ALL) remains debatable. Herein, we determined the clinical significance of TP53mut in 283 adult ALL patients treated with a pediatric-type regimen. TP53mut were found in 11.0% (31) of patients, including 19 cases in adolescent and young adult (AYA) patients and 12 cases in non-AYA patients. Patients with TP53mut had poorer...

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Identifiers

PMID: 37938093
DOI: 10.1080/10428194.2023.2278026

Genes

EFS
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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