Article
Combined prognostic impact of complex karyotype and KIT mutations refines risk stratification in t(8;21) acute myeloid leukemia.
Cancer - 1 Apr 2026
Liu Lin, Shi Yuanfei, Wang Lu, Maleki Goli Maryam, Ghanad Parnia, Zhao Shuqi, Xu Huan, Wang Dongmei, Qi Lingling, Wang Huanping, Chen Zhimei, Tu Jifang, Zhou Junhao, Li Mengyu, Ruan Xiaoling, Jin Jie, Tong Hongyan
Abstract excerpt
BACKGROUND: Acute myeloid leukemia (AML) with t(8;21) is traditionally classified as favorable-risk; however, relapse occurs in 30%-50% of patients, indicating underlying heterogeneity. The prognostic impact and potential synergy of additional cytogenetic abnormalities (ACAs)-specifically complex karyotype (CK)-and KIT mutations remain poorly defined. METHODS: The authors conducted a retrospective cohort study of...
Topics
- Humans
- Leukemia, Myeloid, Acute
- Proto-Oncogene Proteins c-kit
- Female
- Prognosis
- Mutation
- Chromosomes, Human, Pair 21
- Chromosomes, Human, Pair 8
- Translocation, Genetic