Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group.

doi:10.1200/JCO.2015.61.1947

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Article

Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Dec 2015

Klein Kim, Kaspers Gertjan, Harrison Christine J, Beverloo H Berna, Reedijk Ardine, Bongers Mathilda, Cloos Jacqueline, Pession Andrea, Reinhardt Dirk, Zimmerman Martin, Creutzig Ursula, Dworzak Michael, Alonzo Todd, Johnston Donna, Hirsch Betsy, Zapotocky Michal, De Moerloose Barbara, Fynn Alcira, Lee Vincent, Taga Takashi, Tawa Akio, Auvrignon Anne, Zeller Bernward, Forestier Erik, Salgado Carmen, Balwierz Walentyna, Popa Alexander, Rubnitz Jeffrey, Raimondi Susana, Gibson Brenda

Abstract excerpt

PURPOSE: This retrospective cohort study aimed to determine the predictive relevance of clinical characteristics, additional cytogenetic aberrations, and cKIT and RAS mutations, as well as to evaluate whether specific treatment elements were associated with outcomes in pediatric t(8;21)-positive patients with acute myeloid leukemia (AML). PATIENTS AND METHODS: Karyotypes of 916 pediatric patients with t(8;21)-AML...

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PMID: 26573082
DOI: 10.1200/JCO.2015.61.1947
PMCID: PMC5321085

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