Allogeneic hematopoietic stem cell transplantation can improve the prognosis of high-risk pediatric t(8;21) acute myeloid leukemia in first remission based on MRD-guided treatment.

doi:10.1186/s12885-020-07043-5

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Article

Allogeneic hematopoietic stem cell transplantation can improve the prognosis of high-risk pediatric t(8;21) acute myeloid leukemia in first remission based on MRD-guided treatment.

BMC cancer - 15 Jun 2020

Hu Guan-Hua, Cheng Yi-Fei, Lu Ai-Dong, Wang Yu, Zuo Ying-Xi, Yan Chen-Hua, Wu Jun, Sun Yu-Qian, Suo Pan, Chen Yu-Hong, Chen Huan, Jia Yue-Ping, Liu Kai-Yan, Han Wei, Xu Lan-Ping, Zhang Le-Ping, Huang Xiao-Jun

Abstract excerpt

BACKGROUND: Pediatric acute myeloid leukemia (AML) with t(8;21) (q22;q22) is classified as a low-risk group. However, relapse is still the main factor affecting survival. We aimed to investigate the effect of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on reducing recurrence and improving the survival of high-risk pediatric t(8;21) AML based on minimal residual disease (MRD)-guided treatment,...

Topics

Adolescent
Antineoplastic Combined Chemotherapy Protocols
Child
Consolidation Chemotherapy
Core Binding Factor Alpha 2 Subunit
DNA Mutational Analysis
Disease-Free Survival
Female
Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Incidence

Induction Chemotherapy

Leukemia, Myeloid, Acute

Male

Mutation

Neoplasm Invasiveness

Neoplasm Recurrence, Local

Neoplasm, Residual

Source

Open in PubMed Open full text

Identifiers

PMID: 32539815
DOI: 10.1186/s12885-020-07043-5
PMCID: PMC7294617

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