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Article

Independent prognostic significance of TP53 mutations in adult acute myeloid leukaemia with complex karyotype.

International journal of laboratory hematology - 1 Oct 2022

Xu Nan, Lai Yue-Yun, Chen Wen-Min, Jiang Hao, Wang Yu, Wang Xu, Zhao Xiao-Su, Huang Xiao-Jun, Jiang Qian, Qin Ya-Zhen

Abstract excerpt

INTRODUCTION: Adult acute myeloid leukaemia (AML) patients with complex karyotype (CK) generally have unfavourable outcomes. CK commonly co-exists with characteristic chromosomal and genetic abnormalities such as monosomal karyotype (MK), -17 or 17p- [abn(17p)] and TP53 mutations. Their individual prognostic significance needs to be clarified. METHODS: Seventy-three adult CK-AML patients and eleven adult...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35505580
DOI: 10.1111/ijlh.13864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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