Article
Low WT1 transcript levels at diagnosis predicted poor outcomes of acute myeloid leukemia patients with t(8;21) who received chemotherapy or allogeneic hematopoietic stem cell transplantation.
Chinese journal of cancer - 19 May 2016
Qin Ya-Zhen, Wang Yu, Zhu Hong-Hu, Gale Robert Peter, Zhang Mei-Jie, Jiang Qian, Jiang Hao, Xu Lan-Ping, Chen Huan, Zhang Xiao-Hui, Liu Yan-Rong, Lai Yue-Yun, Jiang Bin, Liu Kai-Yan, Huang Xiao-Jun
Abstract excerpt
BACKGROUND: Acute myeloid leukemia (AML) with t(8;21) is a heterogeneous disease. Identifying AML patients with t(8;21) who have a poor prognosis despite achieving remission is important for determining the best subsequent therapy. This study aimed to evaluate the impact of Wilm tumor gene-1 (WT1) transcript levels and cellular homolog of the viral oncogene v-KIT receptor tyrosine kinase (C-KIT) mutations at...
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