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Article

Multidimensional study of the heterogeneity of leukemia cells in t(8;21) acute myelogenous leukemia identifies the subtype with poor outcome

3 Aug 2020

Abstract excerpt

Significance t(8;21) acute myelogenous leukemia (AML) often presents different degrees of aberrant myeloid differentiation. Although most patients respond to current chemotherapy regimens, a sizeable number of patients are prone to relapse. Thus, the cellular heterogeneity and disease outcome may need exploration. Here, by integrating high-throughput DNA/RNA sequencing with phenotypic analysis, heterogeneous...

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PMID: 32747558
DOI: 10.1073/pnas.2003900117

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