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Article

High number of additional genetic lesions in acute myeloid leukemia with t(8;21)/RUNX1-RUNX1T1: frequency and impact on clinical outcome.

Leukemia - 1 Jul 2014

Krauth M-T, Eder C, Alpermann T, Bacher U, Nadarajah N, Kern W, Haferlach C, Haferlach T, Schnittger S

Abstract excerpt

t(8;21)/RUNX1-RUNX1T1-positive acute myeloid leukemia (AML) is prognostically favorable; however, outcome is heterogeneous. We analyzed 139 patients with t(8;21)/RUNX1-RUNX1T1-positive AML (de novo: n=117; therapy-related: n=22) to determine frequency and prognostic impact of additional genetic abnormalities. All patients were investigated for mutations (mut) in ASXL1, FLT3, KIT, NPM1, MLL, IDH1, IDH2, KRAS,...

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Topics

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Share to Chromosomes, Human, Pair 21
Share to Chromosomes, Human, Pair 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Gene Expression Regulation, Leukemic

Share to Nucleophosmin

Share to Oncogene Proteins, Fusion

Share to RUNX1 Translocation Partner 1 Protein

Share to Translocation, Genetic

Source

Identifiers

PMID: 24402164
DOI: 10.1038/leu.2014.4

Genes

RUNX1
EFS
FLT3
ASXL1
CBL
IDH1
IDH2
JAK2
KIT
KRAS
NPM1
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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