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Article

Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2006

Paschka Peter, Marcucci Guido, Ruppert Amy S, Mrózek Krzysztof, Chen Hankui, Kittles Rick A, Vukosavljevic Tamara, Perrotti Danilo, Vardiman James W, Carroll Andrew J, Kolitz Jonathan E, Larson Richard A, Bloomfield Clara D

Abstract excerpt

PURPOSE: To analyze the prognostic impact of mutated KIT (mutKIT) in core-binding factor acute myeloid leukemia (AML) with inv(16)(p13q22) and t(8;21)(q22;q22). PATIENTS AND METHODS: Sixty-one adults with inv(16) and 49 adults with t(8;21), assigned to postremission therapy with repetitive cycles of higher dose cytarabine were analyzed for mutKIT in exon 17 (mutKIT17) and 8 (mutKIT8) by denaturing...

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Share to Acute Disease
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Inversion

Share to Leukemia, Myeloid

Share to Multivariate Analysis

Share to Proto-Oncogene Proteins c-kit

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Share to Translocation, Genetic

Source

Identifiers

PMID: 16921041
DOI: 10.1200/JCO.2006.06.9500

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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