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Predicting viral sensitivity to antibodies using genetic sequences and antibody similarities.

PLoS computational biology - 1 Mar 2026

Shimagaki Kai S, Kher Gargi, Lynch Rebecca M, Barton John P

Abstract excerpt

For genetically variable pathogens such as human immunodeficiency virus (HIV)-1, individual viral isolates can differ dramatically in their sensitivity to antibodies. The ability to predict which viruses will be sensitive and which will be resistant to a specific antibody could aid in the design of antibody therapies and help illuminate resistance evolution. Due to the enormous number of possible combinations, it...

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Identifiers

PMID: 41871140
DOI: 10.1371/journal.pcbi.1014095
PMCID: PMC13020759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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