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Computational analysis of anti–HIV-1 antibody neutralization panel data to identify potential functional epitope residues

10 Jun 2013

Abstract excerpt

Advances in single-cell antibody cloning methods have led to the identification of a variety of broadly neutralizing anti-HIV-1 antibodies. We developed a computational tool (Antibody Database) to help identify critical residues on the HIV-1 envelope protein whose natural variation affects antibody activity. Our simplifying assumption was that, for a given antibody, a significant portion of the dispersion of...

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PMID: 23754383
DOI: 10.1073/pnas.1309215110

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