Article
Macrophages as a therapeutic target to promote diabetic wound healing.
Molecular therapy : the journal of the American Society of Gene Therapy - 7 Sept 2022
Sharifiaghdam Maryam, Shaabani Elnaz, Faridi-Majidi Reza, De Smedt Stefaan C, Braeckmans Kevin, Fraire Juan C
Abstract excerpt
It is well established that macrophages are key regulators of wound healing, displaying impressive plasticity and an evolving phenotype, from an aggressive pro-inflammatory or "M1" phenotype to a pro-healing or "M2" phenotype, depending on the wound healing stage, to ensure proper healing. Because dysregulated macrophage responses have been linked to impaired healing of diabetic wounds, macrophages are being...
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