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Article

Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci.

The Journal of allergy and clinical immunology - 1 May 2018

Martin Lisa J, He Hua, Collins Margaret H, Abonia J Pablo, Biagini Myers Joceyln M, Eby Michael, Johansson Hanna, Kottyan Leah C, Khurana Hershey Gurjit K, Rothenberg Marc E

Abstract excerpt

BACKGROUND: Eosinophilic esophagitis (EoE) is an esophageal inflammatory disease associated with atopic diseases. Thymic stromal lymphopoietin (TSLP) and calpain 14 (CAPN14) genetic variations contribute to EoE, but how this relates to atopy is unclear. OBJECTIVE: The purpose of this study was to explore the relationship between EoE, atopy, and genetic risk. METHODS: EoE-atopy enrichment was tested by using 700...

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Identifiers

PMID: 29129581
DOI: 10.1016/j.jaci.2017.09.046
PMCID: PMC6016040

Genes

TSLP
CAPN14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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