Article
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.
Journal of neuropathology and experimental neurology - 1 Aug 2004
Cataldo Anne M, Peterhoff Corrinne M, Schmidt Stephen D, Terio Nicole B, Duff Karen, Beard Margaret, Mathews Paul M, Nixon Ralph A
Abstract excerpt
The neuronal lysosomal system is a major degradative pathway, induced by cell stress and closely linked to Alzheimer disease (AD) and other neurodegenerative diseases. Here, we show that mutations of presenilin (PS) 1 and 2, which cause familial early-onset AD (FAD), induce more severe lysosomal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.