Article
Hypoxia-induced miR-182-5p regulates vascular smooth muscle cell phenotypic switch by targeting RGS5.
Cell biology international - 1 Nov 2022
Wang Xiaozhou, Xu Xiaolong, Zhu Qinfang, Han Ying, Zhang Wei
Abstract excerpt
In response to vascular injury or alterations in the local environment, such as hypoxia and hypertension, contractile vascular smooth muscle cells (VSMCs) are able to switch to a synthetic phenotype characterized by increased extracellular matrix synthesis with decreased expression of contractile markers. miR-182-5p has recently been reported to play a regulatory role in VSMCs proliferation. However, little is...
Topics
- Cell Movement
- Cell Proliferation
- Cells, Cultured
- Humans
- Hypoxia
- MicroRNAs
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle
- Phenotype
- RGS Proteins