Article
CircLMBR1 inhibits phenotypic transformation of hypoxia-induced pulmonary artery smooth muscle via the splicing factor PUF60.
European journal of pharmacology - 5 Oct 2024
Wang Hongdan, Gao Yupei, Bai June, Liu Huiyu, Li Yiying, Zhang Junting, Ma Cui, Zhao Xijuan, Zhang Lixin, Wan Kuiyu, Zhu Daling
Abstract excerpt
Phenotypic transformation of pulmonary artery smooth muscle cells (PASMCs) contributes to vascular remodeling in hypoxic pulmonary hypertension (PH). Recent studies have suggested that circular RNAs (circRNAs) may play important roles in the vascular remodeling of hypoxia-induced PH. However, whether circRNAs cause pulmonary vascular remodeling by regulating the phenotypic transformation in PH has not been...
Topics
- Pulmonary Artery
- Animals
- Humans
- Mice
- Vascular Remodeling
- Myocytes, Smooth Muscle
- Phenotype
- RNA, Circular
- Muscle, Smooth, Vascular
- Male
- Splicing Factor U2AF