Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pediatric Sepsis: Evolving Subphenotypes, Overlap Syndromes, and the Path to Precision Therapies.

Clinics in chest medicine - 1 Mar 2026

Ham Steven D, Fitzgerald Julie C, Lindell Robert B

Abstract excerpt

Pediatric sepsis is a complex syndrome shaped by developmental considerations, age-specific physiology, immunologic heterogeneity, and hyperinflammatory overlap syndromes. Recent evidence underscores a dynamic interplay between hyperinflammation and immunoparalysis in pediatric patients with sepsis, emphasizing the need for rapid, personalized diagnostic tools. While revised pediatric scoring systems and targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Immunotherapy
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Precision Medicine

Share to Sepsis

Source

Open in PubMed Open full text

Identifiers

PMID: 41651600
DOI: 10.1016/j.ccm.2025.11.001
PMCID: PMC13147271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pediatric Sepsis: Evolving Subphenotypes, Overlap Syndromes, and the Path to Precision Therapies.PMID 41651600Read ↗

Pediatric Sepsis Diagnosis, Management, and Sub-phenotypes.Semantic proximity Read ↗

The landscape of immune dysregulation in pediatric sepsis at a single-cell resolutionSemantic proximity Read ↗

Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.Semantic proximity Read ↗

Multilevel omics for the discovery of biomarkers in pediatric sepsisSemantic proximity Read ↗

Role of Damage-Associated Molecular Patterns and Uncontrolled Inflammation in Pediatric Sepsis-Induced Multiple Organ Dysfunction SyndromeSemantic proximity Read ↗

Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock PhenotypeSemantic proximity Read ↗

Comparative immuno-biology at clinical recognition of early multiple organ dysfunction syndrome in pediatric and adult patients using single-cell transcriptomicsSemantic proximity Read ↗

Genome-wide association study of pediatric bacteremia and sepsisSemantic proximity Read ↗

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19Semantic proximity Read ↗

Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk ModelSemantic proximity Read ↗

Sepsis syndrome in children: can we do better?Semantic proximity Read ↗

Derivation of four computable 24-hour pediatric sepsis phenotypes to facilitate personalized enrollment in early precise anti-inflammatory clinical trialsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.