Article
Systematic identification of variant-specific RNA structure-small molecule interactions exemplified by RNA G-quadruplexes.
Nature communications - 19 Mar 2026
Miyashita Emi, Onizuka Kazumitsu, Chen Yutong, Yoshida Hiroki, Hatayama Hina, Ishikawa Shunya, Yan Peijie, Hasegawa Takahito, Ozawa Mamiko, Maeta Kaho, Nagatsugi Fumi, Saito Hirohide, Komatsu Kaoru R
Abstract excerpt
Individual genetic variations, such as cancer-associated somatic mutations, alter RNA structures, thereby potentially enhancing or inhibiting the binding of RNA-targeting small molecules. However, to date, no approach has been available to identify these variant-specific RNA-small molecule interactions due to technical limitations. Here, we present Binding- and Vinyl-Quinazolinone-Induced Deletion-Based...
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