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A droplet digital LAMP-based lab-on-a-disc system for multiplex allele-specific detection of tumor-derived DNA mutations.

Biosensors & bioelectronics - 1 Apr 2026

Lu Hui, Wang Qin, Tang Xun, Jiang Yu, Shen Jianjiang, Yang Xiao, Jiang Ning, Wang Xiaoming, Yan Feng

Abstract excerpt

The absence of accurate, rapid, fully automated, and cost-effective detection methods has hindered the clinical translation of tumor-derived DNA mutations as cancer biomarkers. Here, we develop a sample-to-answer platform, termed multiplexed droplet digital loop-mediated isothermal amplification-based lab-on-a-disc (mddLAMP-LoD), for rapid and allele-specific detection of cancer-associated mutations. The system...

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PMID: 41500045
DOI: 10.1016/j.bios.2025.118367

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PIK3CA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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