Singlet oxygen-based photoelectrochemical detection of single-point mutations in the KRAS oncogene.

Abstract excerpt

Single nucleotide point mutations in the KRAS oncogene occur frequently in human cancers, rendering them intriguing targets for diagnosis, early detection and personalized treatment. Current detection methods are based on polymerase chain reaction, sometimes combined with next-generation sequencing, which can be expensive, complex and have limited availability. Here, we propose a novel singlet oxygen (1O2)-based...

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• Biosensing Techniques
• DNA Mutational Analysis
• Mutation
• Oncogenes
• Point Mutation