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Innovative PNA-LB mediated allele-specific LAMP for KRAS mutation profiling on a compact lab-on-a-disc device.

Talanta - 15 Aug 2024

Mirlohi Maryam Sadat, Pishbin Esmail, Dezhkam Rasool, Kiani Mohammad Javad, Shamloo Amir, Salami Siamak

Abstract excerpt

Tailored healthcare, an approach focused on individual patients, requires integrating emerging interdisciplinary technologies to develop accurate and user-friendly diagnostic tools. KRAS mutations, prevalent in various common cancers, are crucial determinants in selecting patients for novel KRAS inhibitor therapies. This study presents a novel state-of-the-art Lab-on-a-Disc system utilizing peptide nucleic...

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PMID: 38772176
DOI: 10.1016/j.talanta.2024.126224

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