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RLP system: A single-tube two-step approach with dual amplification cascades for rapid identification of EGFR T790M.

Analytica chimica acta - 25 Jan 2024

Huang Tao, Han Yanxi, Chen Yuqing, Diao Zhenli, Ma Yu, Feng Lei, Wang Duo, Zhang Rui, Li Jinming

Abstract excerpt

BACKGROUND: The detection of cancer gene mutations in biofluids plays a pivotal role in revolutionizing disease diagnosis. The presence of a large background of wild-type sequences poses a challenge to liquid biopsy of tumor mutation genes. Suppressing the detection of wild-type sequences can reduce their interference, however, due to the minimal difference between mutant and wild-type sequences (such as single...

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PMID: 38182396
DOI: 10.1016/j.aca.2023.342126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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