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Programmable Double Peptide Nucleic Acid-Locked Nucleic Acid Molecular Switch Enables Extraction-Free Direct Zygosity Discrimination of Single Nucleotide Polymorphisms.

Analytical chemistry - 30 Jun 2026

Tantu Milkiyas Toru, Shaon Md Akeruzzaman, Haque Farjana, Manjur Omar Hamza Bin, Shrestha Kiran, Islam Md Sajedul, Aktar Sharmin, Nguyen Romario, Qiao Liang, Francis Nidhish, Hanafy Doaa M, Ross Allen G, Shiddiky Muhammad J A, Farhana Fatema Zerin

Abstract excerpt

Accurate discrimination of single-nucleotide polymorphism (SNP) zygosity remains challenging for isothermal amplification platforms, which typically report mutation presence without resolving allelic composition. This limitation is particularly relevant for metabolic dysfunction-associated steatohepatitis (MASH) in which disease susceptibility and progression are strongly influenced by genetic variants that...

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PMID: 42324653
DOI: 10.1021/acs.analchem.6c01648

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PNPLA3

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