Article

Population-Scale, Genotype-First Characterization of Monogenic Diabetes in 374,973 Multi-Ancestry Individuals from the <i>All of Us</i> Research Program

2026-06-22

Abstract excerpt

<h4>OBJECTIVE</h4> To characterize the prevalence and penetrance of maturity-onset diabetes of the young (MODY) in a multi-ancestry population using a genotype-first design. <h4>RESEARCH DESIGN AND METHODS</h4> We analyzed whole-genome sequencing and clinical data from 374,973 unrelated All of Us participants (42.0% non-European ancestry). We identified pathogenic or likely pathogenic (P/LP) variants in 10 esta...

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Literature Corpus work: 6dafc818-3455-52d4-b3c9-15b94a0c0ab6
DOI: 10.64898/2026.06.12.26355541

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