Article
[Gene polymorphisms of Toll-like receptors in Chinese Han children with sepsis in Wenzhou].
Zhonghua er ke za zhi = Chinese journal of pediatrics - 1 Jan 2010
Shan Xiao-ou, Wu Ying, Ye Jing, Ding Zhi-yong, Qian Cai, Zhou Ai-hua
Abstract excerpt
OBJECTIVE: Sepsis remains a serious clinical problem because of high morbidity and mortality. The importance of Toll-like receptors (TLRs) for the induction of immune responses against sepsis was demonstrated in humans. The present study aimed to probe the gene polymorphisms of TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg753Gln) in patients with sepsis among Chinese Han children in Wenzhou, and investigate the...
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