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Article

ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension

25 Mar 2021

Abstract excerpt

Background: Metabolic alterations provide substrates that influence chromatin structure to regulate gene expression that determines cell function in health and disease. Heightened proliferation of smooth muscle cells (SMC) leading to the formation of a neointima is a feature of pulmonary arterial hypertension (PAH) and systemic vascular disease. Increased glycolysis is linked to the proliferative phenotype of...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 33764154
DOI: 10.1161/circulationaha.120.048845

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