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Article

Mutant huntingtin and mitochondrial dysfunction.

Trends in neurosciences - 1 Dec 2008

Bossy-Wetzel Ella, Petrilli Alejandra, Knott Andrew B

Abstract excerpt

Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder that gradually robs affected individuals of memory, cognitive skills and normal movements. Although research has identified a single faulty gene, the huntingtin gene, as the cause of the disease, a cure remains elusive. Strong evidence indicates that mitochondrial impairment plays a key part in HD pathogenesis. Here, we highlight how...

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Identifiers

PMID: 18951640
DOI: 10.1016/j.tins.2008.09.004
PMCID: PMC2613540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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