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Article

Huntington's disease affects mitochondrial network dynamics predisposing to pathogenic mitochondrial DNA mutations.

Brain : a journal of neurology - 3 Jun 2024

Neueder Andreas, Kojer Kerstin, Gu Zhenglong, Wang Yiqin, Hering Tanja, Tabrizi Sarah, Taanman Jan-Willem, Orth Michael

Abstract excerpt

Huntington's disease (HD) predominantly affects the brain, causing a mixed movement disorder, cognitive decline and behavioural abnormalities. It also causes a peripheral phenotype involving skeletal muscle. Mitochondrial dysfunction has been reported in tissues of HD models, including skeletal muscle, and lymphoblast and fibroblast cultures from patients with HD. Mutant huntingtin protein (mutHTT) expression can...

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Source

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Identifiers

PMID: 38195181
DOI: 10.1093/brain/awae007
PMCID: PMC11512592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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