Extended life-span and stress resistance in the Drosophila mutant methuselah.

doi:10.1126/science.282.5390.943

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Article

Extended life-span and stress resistance in the Drosophila mutant methuselah.

Science (New York, N.Y.) - 30 Oct 1998

Lin Y J, Seroude L, Benzer S

Abstract excerpt

Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah (mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of...

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Base Sequence
Cloning, Molecular
DNA Transposable Elements
Drosophila Proteins
Drosophila melanogaster
Female
Food Deprivation
GTP-Binding Proteins
Genes, Insect
Hot Temperature
Insecticide Resistance
Longevity
Male
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 9794765
DOI: 10.1126/science.282.5390.943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9794765-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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