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Article

Improved functional abilities of the life-extended Drosophila mutant Methuselah are reversed at old age to below control levels.

Age (Dordrecht, Netherlands) - 1 Feb 2014

Petrosyan Agavni, Gonçalves Oscar F, Hsieh I-Hui, Saberi Kourosh

Abstract excerpt

Methuselah (mth) is a chromosome 3 Drosophila mutant with an increased lifespan. A large number of studies have investigated the genetic, molecular, and biochemical mechanisms of the mth gene. Much less is known about the effects of mth on preservation of sensorimotor abilities throughout Drosophila's lifespan, particularly in late life. The current study investigated functional senescence in mth and its...

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Identifiers

PMID: 23913251
DOI: 10.1007/s11357-013-9568-1
PMCID: PMC3889883

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