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Article

APOE-mediated sex differences in microvascular pathology and AD-associated proteinopathies in the medial temporal lobe.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2026

Bax Francesco, Oltmer Jan, Auger Corinne A, Bonkhoff Anna, Coughlan Gillian T, Melloni Alexandra, Jaisa-Aad Methasit, Augustinack Jean, Serrano-Pozo Alberto, Frosch Matthew P, Greenberg Steven M, Gomez-Isla Teresa, Hyman Bradley T, van Veluw Susanne J, Perosa Valentina

Abstract excerpt

INTRODUCTION: Cerebral small vessel disease (CSVD) contributes to the development of Alzheimer's disease (AD) dementia and co-occurs with AD-associated proteinopathies. However, how sex modulates the interaction between CSVD and AD-associated proteinopathies in the medial temporal lobe (MTL) remains unclear. METHODS: One hundred fifty-two autopsy cases from the Massachusetts Alzheimer's Disease Research Center...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41830498
DOI: 10.1002/alz.71206
PMCID: PMC13093349

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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