Evidence for Genotype-Specific Optimal Blood Lead Levels for Cancer Risk: MKI67 rs11016073 and APOB rs1367117 in a Female Prospective Cohort.

doi:10.3390/ijms27052317

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Evidence for Genotype-Specific Optimal Blood Lead Levels for Cancer Risk: MKI67 rs11016073 and APOB rs1367117 in a Female Prospective Cohort.

International journal of molecular sciences - 1 Mar 2026

Lubiński Krzysztof, Marciniak Wojciech, Derkacz Róża, Kiljańczyk Adam, Kiljańczyk Milena, Lener Marcin R, Pietrzak Sandra, Cybulski Cezary, Dębniak Tadeusz, Huzarski Tomasz, Kluźniak Wojciech, Sulikowski Tadeusz, Lubiński Jan, Scott Rodney J, Gronwald Jacek

Abstract excerpt

This study's aim was to clarify the regulatory roles of the MKI67 rs11016073 and APOB rs1367117 polymorphisms in the relationship between blood Pb levels and cancer risk. Blood Pb concentrations were measured using inductively coupled plasma mass spectrometry, and genotyping was performed by real-time PCR with TaqMan probes. Cancer incidence was assessed during a mean follow-up of six years and two months. During...

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Apolipoprotein B-100

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Breast Neoplasms

Genetic Predisposition to Disease

Lead

Neoplasms

Polymorphism, Single Nucleotide

Risk Factors

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Identifiers

PMID: 41828541
DOI: 10.3390/ijms27052317
PMCID: PMC12986431

Genes

APOB
MKI67

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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