Blood Lead Level as Marker of Increased Risk of Ovarian Cancer in BRCA1 Carriers.

doi:10.3390/nu16091370

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Blood Lead Level as Marker of Increased Risk of Ovarian Cancer in BRCA1 Carriers.

Nutrients - 30 Apr 2024

Kiljańczyk Adam, Matuszczak Milena, Marciniak Wojciech, Derkacz Róża, Stempa Klaudia, Baszuk Piotr, Bryśkiewicz Marta, Lubiński Krzysztof, Cybulski Cezary, Dębniak Tadeusz, Gronwald Jacek, Huzarski Tomasz, Lener Marcin R, Jakubowska Anna, Szwiec Marek, Stawicka-Niełacna Małgorzata, Godlewski Dariusz, Prusaczyk Artur, Jasiewicz Andrzej, Kluz Tomasz, Tomiczek-Szwiec Joanna, Kilar-Kobierzycka Ewa, Siołek Monika, Wiśniowski Rafał, Posmyk Renata, Jarkiewicz-Tretyn Joanna, Sun Ping, Scott Rodney J, Narod Steven A, Lubiński Jan

Abstract excerpt

BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on BRCA1 carriers remains unexplored. A cohort of 989 BRCA1 mutation carriers underwent genetic testing at the Pomeranian Medical University, Poland. Blood lead levels were...

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PMID: 38732616
DOI: 10.3390/nu16091370
PMCID: PMC11085108

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