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Directionally opposing effects of a shared immune genetic signature on atopic dermatitis and glioblastoma: integrative insights from single-cell and clustered Mendelian randomization analyses

2026-05-04

Abstract excerpt

<h4>Background</h4> Epidemiological studies have consistently documented an inverse association between atopic dermatitis (AD) and glioblastoma (GBM), yet the immunogenetic mechanisms underlying this paradox remain elusive. We hypothesized that distinct immune subsets driven by shared genetic variants exhibiting antagonistic pleiotropy may explain this relationship. <h4>Objective</h4> To dissect the immunogeneti...

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Literature Corpus work
46071a3f-15f5-544e-b7cb-3542fffc5a90
DOI
10.64898/2026.05.01.26352272
Open publication

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Directionally opposing effects of a shared immune genetic signature on atopic dermatitis and glioblastoma: integrative insights from single-cell and clustered Mendelian randomization analysesDOI 10.64898/2026.05.01.26352272
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