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Mendelian Randomization Combined with Single-Cell Transcriptome Analysis Reveals the Role of the Key Gene PCLAF in the Pathogenesis of Atopic Dermatitis

1 Apr 2025

Abstract excerpt

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by itching and rashes, influenced by genetic, environmental, and immune factors. Despite significant research, the molecular mechanisms underlying AD are not fully understood. This study aims to integrate single-cell RNA sequencing (scRNA-seq) with Mendelian Randomization (MR) to uncover genetic and metabolic pathways...

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PMID: 40225314
DOI: 10.2147/ccid.s506139

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