Article
The genetic and mechanistic basis for variation in gene regulation.
PLoS genetics - 1 Jan 2015
Pai Athma A, Pritchard Jonathan K, Gilad Yoav
Abstract excerpt
It is now well established that noncoding regulatory variants play a central role in the genetics of common diseases and in evolution. However, until recently, we have known little about the mechanisms by which most regulatory variants act. For instance, what types of functional elements in DNA, RNA, or proteins are most often affected by regulatory variants? Which stages of gene regulation are typically altered?...
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