Phenocopies in acute lymphoblastic leukemia: Redefining leukemia subtypes in the transcriptomic era.

Abstract excerpt

Phenocopies are leukemias that mirror the transcriptional programs, signaling dependencies and often the clinical behavior of established genetic entities, yet lack their defining lesions. In acute lymphoblastic leukemia (ALL), RNA sequencing (RNAseq) classifiers identify phenocopy subtypes including BCR::ABL1-like, ETV6::RUNX1-like, ZNF384-rearranged-like and KMT2A-rearranged-like, which reproduce canonical...

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• ABL1 gene
• ETV6 gene
• Gene Expression Profiling
• Gene Expression Regulation, Leukemic
• RUNX1 gene