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Pathogenesis and prognostication in acute lymphoblastic leukemia

8 Jul 2014

Abstract excerpt

The process of lymphoid maturation is tightly controlled by the hierarchical activation of transcription factors and selection through functional signal transduction. Acute lymphoblastic leukemia (ALL) represents a group of B/T-precursor-stage lymphoid cell malignancies arising from genetic alterations that block lymphoid differentiation and drive aberrant cell proliferation and survival. With recent advances in...

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PMID: 25184049
DOI: 10.12703/p6-59

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