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The genomic landscape of acute myeloid leukemia: Redefining classifications, ontogeny, and therapeutic strategies.

Seminars in hematology - 1 Jun 2025

Duployez Nicolas, Preudhomme Claude

Abstract excerpt

Over the past decades, the progressive identification of chromosomal abnormalities and gene mutations has transformed acute myeloid leukemia (AML) from a morphologically defined disease into a genetically stratified malignancy. The coexistence and competition of multiple mutations within leukemic clones underscore the complexity of AML and the need for therapeutic strategies that address clonal interference and...

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PMID: 40628574
DOI: 10.1053/j.seminhematol.2025.06.001

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