Article
Homozygous haplotype deficiency reveals deleterious mutations compromising reproductive and rearing success in cattle.
BMC genomics - 18 Apr 2015
Pausch Hubert, Schwarzenbacher Hermann, Burgstaller Johann, Flisikowski Krzysztof, Wurmser Christine, Jansen Sandra, Jung Simone, Schnieke Angelika, Wittek Thomas, Fries Ruedi
Abstract excerpt
BACKGROUND: Cattle breeding populations are susceptible to the propagation of recessive diseases. Individual sires generate tens of thousands of progeny via artificial insemination. The frequency of deleterious alleles carried by such sires may increase considerably within few generations. Deleterious alleles manifest themselves often by missing homozygosity resulting from embryonic/fetal, perinatal or juvenile...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Cell Cycle Proteins
- Fanconi Syndrome
- Frameshift Mutation
- Genome
- Genotype
- Glucose Transporter Type 2
- Haplotypes
- Homozygote