Article
Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis.
Nature communications - 10 Mar 2026
Min Ji-Hee, Castillo-González Claudia, Barcenilla Borja Barbero, Yeo In-Cheol, Xie Xiaoyuan, Bose Sreyashree, Ortiz-Morea Fausto Andres, Liu Di, Canal Eli, Curtis David, Yerram Monisha, Shin Joonyoung, Ulianich Pavel, Phadke Chinmay, He Ping, Wierzbicki Andrzej T, Zhang Junjie, Shakirov Eugene V, Juenger Thomas E, Shippen Dorothy E
Abstract excerpt
Telomeres safeguard the genome, acting as sentinels of oxidative stress and preventing chromosome ends from eliciting a DNA damage response. PROTECTION OF TELOMERES 1 (POT1) is a highly conserved telomere protein, essential for chromosome integrity and telomeric DNA replication. Arabidopsis thaliana encodes two divergent POT1 paralogs: AtPOT1a stimulates telomerase activity, but AtPOT1b function is unknown. Here...
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