Article
Morphological heterogeneity in beta-catenin-mutated hepatocellular carcinomas: implications for tumor molecular classification.
Human pathology - 1 Jan 2022
Torbenson Michael, McCabe Chantal E, O'Brien Daniel R, Yin Jun, Bainter Tiffany, Tran Nguyen H, Yasir Saba, Chen Zongming Eric, Dhanasekaran Renu, Ahn Keun Soo, Roberts Lewis R, Wang Chen
Abstract excerpt
Beta-catenin (CTNNB1) is commonly mutated in hepatocellular carcinoma (HCC). CTNNB1-mutated HCC has important clinical correlates, such as being immune cold and less likely to respond to immune checkpoint inhibitor therapies. It remains unclear, however, if they are a morphologically homogenous group of tumors. To better understand the association between the morphology, CTNNB1 mutations, and other molecular...
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