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Article

Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health.

International journal of epidemiology - 18 Feb 2026

Hatton Alesha A, Brito Nunes Caroline, Lawlor Deborah A, Evans David M

Abstract excerpt

BACKGROUND: During the perinatal period, the fetus can exert profound effects on processes that alter pre- and postnatal maternal physiology. It is possible to investigate the causal effect of offspring perinatal exposures on their mother's health using Mendelian randomization (MR). However, analyses need to be adjusted for maternal genotype to avoid confounding. Such analyses are difficult to perform at scale...

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Identifiers

PMID: 41802218
DOI: 10.1093/ije/dyag030
PMCID: PMC13017718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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