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Extending the Use of Mendelian Randomisation With Non-Inherited Variants to Assess Socially Transmitted Parental Exposures Under Assortative Mating.

Genetic epidemiology - 1 Feb 2026

Woolf Benjamin, Mason Amy, Shapland Chin Yang, Kang Hyunseung, Sallis Hannah M, Burgess Stephen, Munafò Marcus R

Abstract excerpt

A longstanding aim of developmental psychology and epidemiology is to understand the causal effects of parental phenotypes on offspring outcomes. Traditional approaches often fail to account for confounding and reverse causation. We evaluate the use of Mendelian randomisation with non-inherited variants (MR-NIV) to address these limitations. MR-NIV leverages non-inherited genetic variants to instrument the...

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PMID: 41562185
DOI: 10.1002/gepi.70031
PMCID: PMC12820921

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