Article
Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores.
BMC medicine - 1 Feb 2022
Bond Tom A, Richmond Rebecca C, Karhunen Ville, Cuellar-Partida Gabriel, Borges Maria Carolina, Zuber Verena, Couto Alves Alexessander, Mason Dan, Yang Tiffany C, Gunter Marc J, Dehghan Abbas, Tzoulaki Ioanna, Sebert Sylvain, Evans David M, Lewin Alex M, O'Reilly Paul F, Lawlor Deborah A, Järvelin Marjo-Riitta
Abstract excerpt
BACKGROUND: Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms remains unclear. Here, we use Mendelian randomisation (MR) with polygenic risk scores (PRS) to investigate whether associations between maternal pre-/early pregnancy body mass index (BMI) and...
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