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Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization

8 Feb 2019

Abstract excerpt

BACKGROUND: There is considerable interest in estimating the causal effect of a range of maternal environmental exposures on offspring health-related outcomes. Previous attempts to do this using Mendelian randomization methodologies have been hampered by the paucity of epidemiological cohorts with large numbers of genotyped mother-offspring pairs. METHODS: We describe a new statistical model that we have created...

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PMID: 30815700
DOI: 10.1093/ije/dyz019

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