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Article

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study.

PLoS medicine - 1 Jan 2017

Richmond Rebecca C, Timpson Nicholas J, Felix Janine F, Palmer Tom, Gaillard Romy, McMahon George, Davey Smith George, Jaddoe Vincent W, Lawlor Debbie A

Abstract excerpt

BACKGROUND: It has been suggested that greater maternal adiposity during pregnancy affects lifelong risk of offspring fatness via intrauterine mechanisms. Our aim was to use Mendelian randomisation (MR) to investigate the causal effect of intrauterine exposure to greater maternal body mass index (BMI) on offspring BMI and fat mass from childhood to early adulthood. METHODS AND FINDINGS: We used maternal genetic...

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Identifiers

PMID: 28118352
DOI: 10.1371/journal.pmed.1002221
PMCID: PMC5261553

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