Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha-Amidating Monooxygenase Activity in Synovial Fibroblasts.

doi:10.1002/art.70123

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Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha-Amidating Monooxygenase Activity in Synovial Fibroblasts.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Sept 2026

Sheridan Kevin J, Dorris Emma R, Pimenta Maria Inês, Falkov Jemma, Fisher Matthew, Pledger Sam, Devey Hector, Muthana Munitta, Shields Denis C, Mains Richard E, Eipper Betty A, Buckley Christopher D, Wilson Anthony G

Abstract excerpt

OBJECTIVE: Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. METHODS: Expression of surrounding genes was compared among rs26232 genotypes. Publicly available databases were used to correlate expression with RA inflammation and single-cell synovial distribution. Inhibition...

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PMID: 41797318
DOI: 10.1002/art.70123
PMCID: PMC13507597

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